Open Stent Solution (OSS) is a French MedTech start-up company developing the first open-stent heart valve, a paradigm shift in transcatheter mitral valve replacement. The company was founded by senior cardiac surgeon doctor Doron Carmi, who envisioned a novel approach to overcome the limitations of conventional cylindrical stents to treat patients suffering from severe mitral valve regurgitation. The company's unique heart valve supported by a ribbon-shaped stent structure represents a paradigm shift in transcatheter valve replacement. The company has built a team of world-renowned executives, skilled medtech engineers, and leading scientific and medical experts. OSS recently closed a €2.5 million Seed financing round to support its TMVR device development. www.openstentsolution.com 1. Paul Sorajja, MD Transcatheter Therapy for Mitral Regurgitation Clinical Challenges and Potential Solutions Circulation. 2017;136:404–417 2. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez- Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368:1005–1011. doi: 10.1016/S0140-6736(06)69208-8. 3. Mirabel M, Iung B, Baron G, et al. What are thecharacteristics of patients with severe, symptomatic,mitral regurgitation who are denied surgery? Eur Heart J 2007;28:1358–65. SOURCE Open Stent Solution