BIORCHESTRA, with offices in Daejeon, South Korea, and Cambridge, Massachusetts, USA, is an innovative biotech developing ribonucleic acid (RNA) based therapeutics. Our goal is to change the therapeutic paradigm from symptoms treatment to diseases modifying therapeutics in neurodegenerative and other diseases. The BMD is a therapeutic agent development platform that can control microRNAs that regulate multiple messenger RNAs (mRNAs) involved in pathological factors related to diseases. We believe that exclusively targeting single pathological protein, such as Aβ or tau, like most candidate AD therapies of other pharmaceutical companies is too late in the disease course to halt the progression of AD. This upstream regulation with anti-sense oligonucleotide aims to reverse the epigenetic changes in the AD brain induced by the overexpression of target microRNA-485-3p, which we have proven to induce Aβ/tau production, cognitive impairment and a reduction in synaptic plasticity. We have developed proprietary drug delivery system (BDDSTM) for commercial drug development. Delivering the ASO via intravenous injection route, we observed target microRNA knock-down efficacy not only in cortex but also deep brain such as hippocampus even striatum and spinal cord as well. For further information visit: www.biorchestra.com Biorchestra Named Awardee in NYC Innovation QuickFire Challenge on Neuroscience - News | JLABS (jnjinnovation.com) Speakers | RNA Leaders (lsxleaders.com) Oligonucleotide-Based Therapeutics Conference (diaglobal.org) SOURCE BIORCHESTRA Co., Ltd.